Stipend for PhD student in the Department of Microbiology available from 1st October 2018. The closing date for applications is the 24th September 2018.
Position in the project: PhD student
Scientific discipline: Microbiology, immunology
Job type (employment contract/stipend): Stipend
Remuneration amount/month: 3 500 PLN (non-taxable)
Position starts on: 1.10.2018
Maximum period of contract: 36 months
Institution: Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow
Project leader: dr Aleksander Grabiec
Project title: “Epigenetics of periodontitis: DNA methylation in disease development and as a potential therapeutic target.”
Application deadline: 24.09.2018
Project description:
The aim of this project is to analyze pathological changes in DNA methylation in gingival cells from patients with periodontitis, identify the influence of Porphyromonas gingialis on DNA methylation in these cells and characterize its biological consequences. Studies performed within this project will not only improve our understanding of this disease, but can also facilitate identification of new therapeutic targets, constituting a foundation for testing new drug classes in the treatment of periodontal disease in the future.
Key responsibilities:
- In vitro and in situ studies of global and promoter-specific changes in DNA methylation in gingival fibroblasts (GFs), periodontal ligament fibroblasts (PLFs) and in total gingival tissue.
- Determination of the role of P. gingivalis infection and inflammation in promoter-specific DNA methylation in gingival cells.
- Functional studies of biological consequences of altered DNA methylation in gingival cells.
Profile of candidates/requirements:
- MSc degree (or equivalent) in biotechnology, biochemistry or any related field of life sciences.
- Strong experience in primary eukaryotic cell culture and in basic cell biology techniques (ELISA, Western Blot, qPCR) evidenced by results presented in MSc thesis or publication.
- 3. Experience in culturing anaerobic bacteria.
- Experience in epigenetic studies (DNA and histone modification, regulation of epigenetic enzymes) would be an advantage.
- Fluency in written and spoken English.
- Good skills in work organization, planning and keeping experimental track record.
- High level of independence, determination and reliability, willingness to work outside of standard office hours.
- Ability to work in a team.
Required documents:
- Application/motivation letter
- CV including description of experience in laboratory work.
- Copy of a MSc degree
- A statement of knowledge and acceptance of the rules on intellectual property and legal protection of intellectual property Forms for points 3 and 5 can be downloaded from www.dso.uj.edu.pl/druki-do-pobrania/dokumenty-dla-kandydatow-pracownikow
- Contact information of at least one reference.
Please submit the following documents to: aleksander.grabiec@uj.edu.pl
Please include the following statement in your application:
“I hereby give consent for my personal data included in my application to be processed for the purposes of the recruitment process under the Personal Data Protection Act as of 29 August 1997, consolidated text: Journal of Laws 2016, item 922 as amended.”
